Lipid Disorders (Cholesterol) Treatment

Lipid Disorders Treatment

Higher low-density lipoprotein (LDL) cholesterol concentrations and lower high-density lipoprotein (HDL) lvels are associated with an increased risk of CHD. Cholesterol lowering therapy reduces the relative risk of CHD events, with the degree of reduction proportional to the reduction in LDL cholesterol achieved. The absolute benefits of screening for-and treating-abnormal lipid levels depend on the presence and number of other cardiovascular risk factors. 


If other risk factors are present, cardiovascular risk is higher and the benefits of therapy are greater. Patients with diabetes mellitus or known cardiovascular disease are at still higher risk and have larger benefits from reduction in LDL cholesterol.


    Evidence for the effectiveness of statin-type drugs is better than for the other classes of lipid-lowering agents or dietary changes specifically for improving lipid levels. Multiple large randomized, placebo-controlled trials have demonstrated important reductions in total mortality, major coronary events, and strokes with lowering levels of LDL cholesterol by statin therapy for patients with known cardiovascular disease. Statins also reduce cardiovascular events for patients with diabetes mellitus. for patients with no previous history of cardiovascular events or diabetes, the 2009 JUPITER trial showed that statins reduce coronary events relatively similarly for both men and women 

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